Urwego rwa GMP Tirzepatide yo gutera inshusho Ishusho

Urwego rwa GMP Tirzepatide yo gutera inshinge

Ibisobanuro bigufi:

Tirzepatide yakozwe kurubuga rwa GMP hamwe na DMF ibyangombwa kugirango bigufashe kwiyandikisha.

Dufite imirongo 16 yumusaruro ufite ubushobozi bunini buhagije mubushinwa kugirango tumenye vuba kandi vuba.

Niba ufite ikibazo, nyamuneka twohereze iperereza, tuzagusubiza.

Ohereza imeri kuri twe

Ibicuruzwa birambuye

Ibicuruzwa

Ibisobanuro byihuse

Izina rusange:	Tirzepatide
Cas No.:	2023788-19-2
Inzira ya molekulari:	C225H348N48O68
Uburemere bwa molekile:	4813.45 g / mol
Urukurikirane:	H-Tyr- {Aib} -Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile- {Aib} -Leu-Asp-Lys-Ile-Ala-Gln- {diacid-gamma-Glu - (AEEA) 2-Lys} -Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-NH2
Kugaragara:	Ifu yera
Gusaba:	Tirzepatide ni imiti irimo kwigwa kugirango ikoreshwe mu kuvura diyabete yo mu bwoko bwa 2.Ni mubyiciro byibiyobyabwenge byitwa diglucose-biterwa na insulineotropique peptide (GIP) na glucagon isa na peptide-1 (GLP-1) reseptor agonist.Tezepatide ikora mukubyutsa GIP na GLP-1 mumubiri.Izi reseptors zigira uruhare runini mugutunganya isukari yamaraso hamwe na metabolism.Mugukoresha izo reseptors, tezepatide yongera umusaruro wa insuline kandi igabanya ururenda rwa glucagon, imisemburo izamura isukari mu maraso.Itinda kandi gusiba gastric kandi ikanafasha kugabanya urugero rwisukari yamaraso.Igeragezwa rya Clinical ryerekanye ko tilsiparatide ishobora kugenzura neza urugero rw'isukari mu maraso ku barwayi ba diyabete yo mu bwoko bwa 2.Byagaragaye kandi mu guteza imbere kugabanya ibiro, iyi ikaba ari inyungu yiyongera ku bantu benshi barwaye diyabete yo mu bwoko bwa 2 bafite ikibazo cyo gukomeza ibiro byiza.Kimwe mu byiza bya tezeparatide nuburyo bwayo buri cyumweru bwo kunywa, bushobora kongera ubworoherane no kubahiriza uburyo bwo kuvura.Ibi birashobora kugirira akamaro cyane abantu bafite ikibazo cyo kubahiriza gahunda yimiti ya buri munsi cyangwa bahitamo gahunda yo kuvura neza.Twabibutsa ko tilsiparatide ikiri mu iperereza kandi ikaba itaremerwa gukoreshwa n’inzego zishinzwe kugenzura.Ubundi bushakashatsi burakenewe kugirango umenye umutekano wigihe kirekire ningirakamaro no kumenya ingaruka zose zishobora kubaho.Muri make, tilsiparatide numuti mushya urimo gukorwaho iperereza kugirango uvure diyabete yo mu bwoko bwa 2.Ibikorwa byayo bibiri kuri reseptor ya GIP na GLP-1 bifite ubushobozi bwo kunoza glycemic no kugabanya ibiro.Nyamara, ubushakashatsi burakenewe mbere yuko tilsiparatide ishobora gusabwa nkuburyo bwo kuvura abantu barwaye diyabete yo mu bwoko bwa 2.
Ipaki:	aluminium foil umufuka cyangwa aluminium TIN cyangwa nkuko umukiriya abisabwa

Ibyiza byacu

1	Abatanga umwuga kuri peptide APIs ziva mubushinwa.
2	Imirongo 16 yumusaruro ifite ubushobozi bunini bwo gukora hamwe nigiciro cyo gupiganwa
3	DMF iboneka hamwe nibyangombwa byizewe.